Pharmacogenetics: The Scientific Basis
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منابع مشابه
I-33: Pharmacogenetics of Reproductive Medicine
Adverse drug reactions (ADRs) are a major problem in drug therapy and drug development. Inter-individual genetic differences can have significant roles in determining an individual’s susceptibility to ADRs. The rapid development of techniques in the area of genome analysis has put the scientific community in a power position and facilitated identification of new pharmacogenomic biomarkers that ...
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Pharmacogenetics is the study of the genetic basis for variation in drug response. In this broadest sense, pharmacogenetics encompasses pharmacogenomics, which employs tools for surveying the entire genome to assess multigenic determinants of drug response. Until the technical advances in genomics of the last few years, pharmacogenetics proceeded using a forward genetic, phenotype-to-genotype a...
متن کاملPharmGKB: A Resource to Link Genotype and Phenotype in Pharmacogenetics
The PharmGKB (http://www.pharmgkb.org/) is a pharmacogenetics and pharmacogenomics knowledge base built to support the representation, storage, analysis and dissemination of genotype and phenotype data. We have collected genetic sequence data from research centers in which polymorphic variations in genes of pharmacogenetic interest have been characterized in particular populations. PharmGKB als...
متن کاملشناسایی موضوعات نوظهور در حوزه ژنتیک: یک تحلیل علم‌سنجی
Introduction Genetics is a broad issue which is associated with diversity and inheritance in all the living beings. Numerous researches have been implemented in this sphere. Meanwhile, significant steps have been taken during the past few years including identification of active research fields of the area as well as recognition of scientific literature in the sphere. This study, therefore, ...
متن کاملPharmacogenetics in rheumatology: the prospects and limitations of an emerging field.
OBJECTIVES To review the fundamental concepts of pharmacogenetics and analyse how the broad principles of this rapidly emerging field may influence the treatment of rheumatic disease in future. METHODS The names of common rheumatic drugs and the terms 'pharmacogenetics', 'pharmacogenomics' and 'genetic polymorphism' were used as keywords to search the Medline and Current Contents databases. G...
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تاریخ انتشار 2017